Influenza A virus Essay Example | Topics and Well Written Essays - 500 words

Influenza A virus - Essay ExampleThe envelope has two outdoors glycoproteins called neuraminidase and hemagglutinin, the latter gets attached to the host cell prior to viral penetration. Often the HA protein undergoes several antigenic changes, such genomic alterations lead to phenotypic changes thus challenging the development of vaccines against grippe virus. A. Maher andA virulent influenza A virus in humans is responsible for the contagious disease of the respiratory tract leading to chagrin of the epithelial tissues. The infection then extends to the bronchioles and alveoli resulting in interstitial pneumonia. A susceptibility to bacterial super infection is not uncommon. The infection slowly affects extra respiratory tissues leading to myocarditis, myositis, parotitis, encephalopathy and Reye-Jhonson syndrome. T. Kuiken, G. F. Rimmelzwaan, G. Van Amerongen and A. D. M. E. OsterhausFor most data-based studies concerned with animal stupefys, mouse is widely used .The low cos t combined with its small coat permits researchers to conduct large scale studies. Mouse is also considered suitable as a mammalian model for the studies concerning pathogenesis and immunity of human H5N1 influenza virus mainly due to the fact that this virus replicates very in effect and efficiently in the lungs of mouse without any adaptation.